"I'm super excited," Spears said Friday. "The emotions have built up through the week and I can't wait to get back out there."
Spears was placed on injured reserve after suffering a high ankle sprain in the preseason opener against the Tampa Bay Buccaneers on Aug. 9.
The injury happened just before halftime when Spears caught a pass out of the backfield for a 13-yard gain. Spears had a procedure done on the ankle before he started the rehab process. He worked on a side field over the last couple of weeks with Titans trainers.
Titans coach Brian Callahan said before the season that he wanted a more balanced workload between Spears and Tony Pollard, who had 260 carries last season.
"In a perfect world, it's a healthier division of labor [between Pollard and Spears]," Callahan said in July. "I like really both of those players a lot. I think we can do a better job of managing that load so they both play a little more evenly."
The Titans also placed safety Mike Brown on injured reserve due to a knee injury. Wide receiver James Proche II and defensive back Kendall Brooks got the game day elevations from the practice squad.