Where to watch Inter Milan vs. RB Leipzig live stream, TV channel, start time, lineups, prediction for Champions League match

Inter Milan will host RB Leipzig at the iconic San Siro in a high-stakes Champions League clash on Tuesday.

While the Italian giants are looking to extend their unbeaten run in Europe, Leipzig is in desperate need of a lifeline to keep their campaign alive.

Simone Inzaghi's men are thriving, losing just once across 16 games in all competitions this season. Their defensive wall, led by Alessandro Bastoni, has been a major factor in their success.

Leipzig, on the other hand, is staring at direct elimination after four consecutive defeats in the European competition. including a disappointing 3-1 loss at Celtic Park. A fifth consecutive defeat would equal their longest losing streak in the competition's history.

The Sporting News looks at the key details ahead of this game, including how to watch the match, kickoff times and the latest lineup news.

Here's how to watch this Champions League match in the U.S.:

Hakan Calhanoglu will remain sidelined due to a thigh injury sustained on international duty. Kristjan Asllani is likely to start in place of him.

Francesco Acerbi remains a doubt after being forced off early in the weekend win over Verona.

Inter Milan predicted XI (3-5-2, right to left): Sommer (GK) -- Bisseck, De Vrij, Bastoni -- Dumfries, Barella, Asllani, Mkhitaryan, Dimarco -- Thuram, Taremi.

Injured: Martinez (doubtful), Calhanoglu, Acerbi (doubtful)

Suspended: None

RB Leipzig's injury woes continue to mount as they prepare for their must-win game. Xavi Simons and David Raum are sidelined with ankle injuries, while Eljif Elmas and Yussuf Poulsen also remain unavailable after picking up injuries on international duty.

Young defender El Chadaille Bitshiabu has suffered an injury in training and will not be available.

RB Leipzig predicted XI (3-4-3, right to left): Gulacsi (GK) -- Klostermann, Orban, Lukeba -- Henrichs, Haidara, Seiwald, Nusa -- Baumgartner; Openda, Sesko

Injured: Simons, Raum, Elmas, Poulsen, Bitshiabu

Suspended: None

Inter Milan's strong defense and excellent form make them clear favorites at home. On the other hand, Leipzig's recent struggles and injury problems make their challenge even tougher. Inter are likely to dominate the game and secure a comfortable win.